Renal Involvement in Sarcoidosis

Introduction: Sarcoidosis is a granulomatous systemic disease. Renal damage rare but it can evolve to chronic renal failure (CRF). The aim of our work describe the clinical, paraclinical, histological and evolutionary profile involvement during sarcoidosis identify progression factors leading CRF. Materials Methods: This retrospective descriptive study from January 2009 December 2022. We collected medical records patients with involvement. To CRF we identified two groups patients: group normal function that developed Results: included in 17 sarcoidosis. Their mean age was 45 ± 14.7 years sex ratio 0.4. revealing 76% cases. diagnosed 88% patients. Proteinuria positive 76.5% cases, leukocyturia 59% hematuria 41% biopsy performed 15 showing tubulointerstitial nephropathy all biopsies. Epithelioid gigan-to-cellular granuloma without caseous necrosis found 46% Associated glomerular such as segmental focal hyalinosis 2 Corticosteroid therapy initiated for median duration months. Normalization achieved patients, while 59%, i.e. 10 retained CRF, including who were on dialysis. showed statistically significant relationship between evolution towards presence interstitial fibrosis > 25%. Conclusion: Despite its rarity, be sarcoidosis, which condition prognosis lead Its detection allows an early diagnosis treatment.